Targeting Biofilm of MDR Providencia stuartii by Phages Using a Catheter Model

Providencia spp. are emerging pathogens mainly in nosocomial infections. stuartii particular is involved urinary tract infections and contributes significantly to the high incidence of biofilm-formation catheterized patients. Furthermore, recent reports suggested a role for multiple drug resistant (MDR) P. hospital-associated outbreaks which leads excessive complications resulting challenging treatments. Phage therapy currently one most promising solutions combat antibiotic-resistant However, number available phages targeting extremely limited, restricting use phage such cases. In present study, we describe isolation characterization 17 lytic temperate bacteriophages clinical isolates as part Israeli Bank (IPB). These phages, isolated from sewage samples, were evaluated host range activity effectively eradicated 95% tested bacterial strains different geographic locations displaying wide antibiotic resistance. Their demonstrated on agar plates, planktonic cultures, biofilm formed catheter model. The results suggest that these can potentially be used treatment general particular.